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MHC monomers and tetramers

Analysis and monitoring of antigen-specific T cells is pivotal to advancing our understanding of immune responses, improving diagnostics, developing vaccines, and tailoring treatments for cancer, infectious diseases, autoimmune diseases, transplantation, and allergy. It is a key component of cellular research aiming to harness the immune system for therapeutic purposes.

T-cell receptors (TCRs) on T-cell surfaces interact with Major Histocompatibility Complex (MHC) molecules presenting specific peptide sequences from intracellular protein degradation. The two major subsets of T cells, CD8+ and CD4+T cells, are restricted by MHC Class I and Class II MHC molecules, respectively. The interactions between peptide-MHC (pMHC) complexes and cognate TcR’s are short lived and of low affinity. By way of multimerization of four peptide-MHC molecules on a streaptavidin scaffold, tetramers increases the avidity of the pMHC:TcR interaction by engaging several of the TcRs expressed by a specific T cell thereby stabilizing the interaction. This allows for direct and specific staining of the T cells

Explore the HLA Diversity

immunAware provides high-quality MHC tetramers that enable the detection and analysis of antigen-specific T cells in flow cytometry or fluorescence microscopy; tetramers can be labelled with phycoerythrin (PE), allophycocyanin (APC), or Brilliant Violet™ 421 (BV421).

Our HLA repertoire covers 90+ HLA class I, 15 HLA class II allotypes, allowing you to address the human HLA diversity. We provide custom production of pMHC mono- or tetramers, binding and stability analysis of pMHC complexes according to you needs.

We have also developed highly active peptide receptive of MHC class I molecules (easYmers®) which allows you to produce custom peptide-MHC tetramers in your own lab or perform binding analysis of peptides and peptide libraries.

Contact us for more information and let us help you achieve your research goals.