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Discover Peptide-Specific T Cells with immunAware reagents and services.

A tetramer assay, or tetramer stain, is a powerful technique designed to identify and quantify peptide-specific, MHC-restricted T cells at the single cell level. Due to the low affinity of this interaction, traditional flow cytometry struggles to detect the interaction between a monomeric peptide-MHC complex (pMHC) and its corresponding T cell receptor (TcR).

However, multimerization of biotinylated pMHC e.g. using streptavidin to tetramerize the monomeric peptide-MHC complexes, significantly enhances the avidity of the pMHC complexes towards any T cells with T cell receptors of the corresponding peptide-specificity and MHC-restriction. This heightened avidity allows for the precise and reliable single-cell detection, enumeration and characterization of specific T cells, providing valuable insights into specific immune responses and aiding groundbreaking research in immunology. Explore the depths of antigen-specific T cell analysis with our cutting-edge tetramer assay, revolutionizing the way we understand immune responses.

For more information or to inquire about our tetramer assay services, please contact us at


immunAware has three product lines for MHC class I:

immunAware has two product lines for MHC class II: